Menopause constitutes a sizable population of the adult womans life, and it is resonable to consider that most women will benefit from hormone replacement therapy. Also, it is important to realized that cardiovascular disease is a major cause of
morbidity and death in the menopausal patient.
To study the effects of different dose of progesterone on lipoprotein metabolism, we treated two groups of postmenopausal women with for 25 days with conjugated equine estrogen 0.625 mg per day and different sequential estrogen-progesterone
regimens as
followes : Group I received medroxyprogesterone acetate, 2.5 mg per day, from day 14 to day 25 of the cycle ; Group II, medroxyprogesterone acetate, 5mg per day.
The data demonstrated a beneficial effect in lipoprotein profiles, that total cholesterol decreased in two groups by 8.6 to 11.7 percent from the base line values.
Low density liporprotein cholesterol decrease in two groups by 18.5(group I) and 32.7(group II) percent in post HRT 12 months. High density lipoprotein cholesterol increase ceride increase during initial 6 months period (6.5~28.3 percent)and
decrease
during post 12 months period in both groups.
Our result suggest that medroxyprogesterone acetate, especially 5 mg per day have the beneficial effect of postmenopausal estrogen treatment on HDL-cholesterol and so, the favorable lipoprotein profile offer protection to the cardiovascular
system.
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